Diabetes information and solutions utilizing medical cannabis.
When you hear the word “diabetes,” your first thought is likely about high blood sugar. Blood sugar is an often-underestimated component of your health. When it’s out of whack over a long period of time, it could develop into diabetes. Diabetes affects your body’s ability to produce or use insulin, a hormone that allows your body to turn glucose (sugar) into energy.
To date, clinical studies have largely focused on phytocannabinoids, including whole cannabis, THC or its synthetic analogue (dronabinol), or nabiximols which are combinations of THC and cannabidiol (e.g. Sativex) to treat neuropathic pain of various origins. In these studies, the phytocannabinoids are most commonly delivered by inhalation (vaporized, smoked), orally, or oromucosally.
CBD vs. THC: What’s the Difference?
To understand proper dosing of medical cannabis, one must first understand the 2 major components of Cannabis. This includes Cannabidiol (CBD) and tetrahydrocannabinol (THC), two natural compounds found in plants of the Cannabis genus.
CBD is found primarily in extractions from the hemp plant. Bud and Herbs delivery of CBD includes gels, chewable tablets, oils, supplements, extracts, and more.
THC is the main psychoactive compound in marijuana that gives the high sensation. It can be consumed by smoking marijuana. It’s also available in Bud and Herbs products in oils, Chew tablet’s, tinctures, capsules, and more.
Both compounds interact with your body’s endocannabinoid system but they have very different effects.
CBD vs. THC: Chemical structure
Both CBD and THC have the exact same molecular structure: 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms. A slight difference in how the atoms are arranged accounts for the differing impacts on your body.
Both CBD and THC are chemically similar to your body’s own endocannabinoids. This allows them to interact with your cannabinoid receptors. The interaction impacts the release of neurotransmitters in your brain. Neurotransmitters are chemicals responsible for relaying messages between cells and have roles in pain, immune function, stress, sleep, to name a few.
CBD vs. THC: Psychoactive components
Despite their similar chemical structures, CBD and THC don’t have the same psychoactive effects. In fact, CBD is a nonpsychoactive compound. That means it doesn’t produce the “high” associated with THC.
THC binds with the cannabinoid 1 (CB1) receptors in the brain. It produces a high or sense of euphoria.
CBD binds very weakly, if at all, to CB1 receptors. In fact, it can interfere with the binding of THC and dampen the psychoactive effects.
While there is clinical evidence that cannabis and its extracts have some efficacy against chronic neuropathic pain, the current meta-analyses suggest that this efficacy is relatively modest compared to placebo. It might be noted, however, that cannabis and cannabinoids consistently improve sleep and disability index despite the fact that they do not always significantly improve pain. Cannabinoids are generally well-tolerated by patients and there is good evidence to suggest that tolerance does not develop to their beneficial effects. In fact, a higher proportion of patients respond better to longer term treatment, suggesting that cannabinoids may offer a safer alternative than some current treatments.